Mission Statement

prekash
USC, VP for Research and Center Director
mitzi
Center Co-Director and Chair, Dept. Pathology, Microbiology, Immunology

The Center for Dietary Supplements and Inflammation (CDSI) is the second  COBRE Center supported by National Institute of Health (NIH) at USC. The other, Center for Colon Cancer Research, started in 2002 is now ready for its 3rd renewal cycle application. The CDSI was awarded $10.1 million over a period of five years starting September 1, 2012.

The Center integrates faculty from six of USC’s colleges to conduct research on the mechanism of regulation of inflammation by dietary supplements during  chronic inflammatory processes associated with cancer, obesity, hypertension, diabetes, Alzheimer's and several other autoimmune diseases.The highly successful, productive and quality research of a 5 year, $ 6 million NIH Center for Complementary and Alternative Medicine (CAM) Nagarkatti, P., (Center Director),is the contributing factor for the recent CDSI (COBRE) award to USC School of Medicine.

The long term objective of the CDSI is to build a self-sustaining, nationally recognized multi-disciplinary Center for dietary supplements and inflammation research, by promoting innovation, faculty entrepreneurship, collaborative research projects and clinical/translational research. The initial projects of the Center include:

1) Study the role of a new Chinese herb-derived selective Toll-like receptor antagonist (Sparstolonin B ) as an anti-inflammatory agent to  treat atherosclerosis.

2) Anti-inflammatory capabilities of Plant Polyphenols for the treatment of Alzheimer’s Disease.

3) American Ginseng-mediated  autophagy and suppression of inflammation in pathological cardiac  remodeling and dysfunction and

4) Macrophage-induced inflammation in high fat diet enhanced breast cancer: benefits of Quercetin.

The Center is supported by state-of-art Microscopy and Imaging Core, Flow Cytometry and  Cell Sorting Core, Immune Monitoring Core. and the Administrative core.

The Center is funded by National Institute of General Medical Sciences (NIGMS) unit of National Institutes of Health (NIH).