Diet-induced regulation of inflammation in prostate cancer

Principal Investigator:  Dev Karan

The global aim of our research includes understanding the role of inflammation-associated molecules in the development and progression of prostate cancer and harnessing the power of immune system to improve its preventive and therapeutic efficacy against developing neoplastic cells and/or established cancer cells.

Project PI: Dev Karan

The goal of the current study is to expand on our observation that Withaferin-A (WFA) from the plant Withania somnifera inhibits expression of NLRP3 inflammasome (multi-protein complexes including NLRP3, IL-1β, IL-18) and therefore test the hypothesis that intake of dietary agent WFA will provide an anti-inflammatory environment in the prostate gland to prevent tumor development. In this proposal we will 1) Determine the mechanism of WFA-mediated regulation of inflammatory cytokines and 2) Determine WFA-targeted modulation of inflammation in vivo and inhibition of prostate cancer cell growth.

We will specifically test WFA-induced polarization (tumor promoting or tumor suppressive) of macrophages in the prostate gland  and understand the role of macrophage inhibitory cytokine-1 (MIC-1) and  assess the WFA-induced functional activity of  NK cells in vitro and in immune competent mice.

PubMed Link