American Ginseng-mediated Autophagy and suppression of inflammation in Pathological Cardiac Remodeling and Dysfunction

Principal Investigator: Taixing Cui
PubMed

The global aim of our research includes studying role of  inflammation in cardiovascular disease  (CVD) with emphasis on identifying alternative therapeutic strategies to manage complications of CVD. The goal of the current study is to expand on our preliminary results that the protective effect of American ginseng extract against cardiac dysfunction is 1) due to enhanced autophagy and

taxing cui
Project PI: Taixing Cui
suppression of oxidative stress through activation of Nrf2 signaling in cardiomyocytes and 2) a unique modulatory effect on inflammatory responses in macrophages via orchestrating NF-kB and STAT pathways. In this proposal we will 1) Determine the role of autophagy and Nrf2 in regulating the American ginseng-mediated suppression of oxidative stress and inflammatory cytokine production in macrophages as well as oxidative stress, hypertrophic growth and cell death in cardiomyocytes. 2) Determine the efficacy of hexane fraction of American ginseng on autophagy and Nrf2 pathway in cardiomyocytes and macrophages respectively. 3) Determine the efficacy of hexane fraction of American ginseng on the suppression of maladaptive cardiac hypertrophy and dysfunction via activating both myocardial autophagy and Nrf2 in the heart. These studies may have profound implications on the clinical utility of American ginseng as an alternative medicine for the treatment of heart diseases.

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